Ontology highlight
ABSTRACT:
SUBMITTER: Chuntakaruk H
PROVIDER: S-EPMC10864397 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Chuntakaruk Hathaichanok H Hengphasatporn Kowit K Shigeta Yasuteru Y Aonbangkhen Chanat C Lee Vannajan Sanghiran VS Khotavivattana Tanatorn T Rungrotmongkol Thanyada T Hannongbua Supot S
Scientific reports 20240213 1
The prevalence of HIV-1 infection continues to pose a significant global public health issue, highlighting the need for antiretroviral drugs that target viral proteins to reduce viral replication. One such target is HIV-1 protease (PR), responsible for cleaving viral polyproteins, leading to the maturation of viral proteins. While darunavir (DRV) is a potent HIV-1 PR inhibitor, drug resistance can arise due to mutations in HIV-1 PR. To address this issue, we developed a novel approach using the ...[more]