Multivalent Calixarene Complexation of a Designed Pentameric Lectin.
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SUBMITTER: Flood RJ
PROVIDER: S-EPMC10865345 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
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Multivalent Calixarene Complexation of a Designed Pentameric Lectin.
Flood Ronan J RJ Cerofolini Linda L Fragai Marco M Crowley Peter B PB
Biomacromolecules 20240116 2
We describe complex formation between a designed pentameric β-propeller and the anionic macrocycle sulfonato-calix[8]arene (<b>sclx</b><sub><b>8</b></sub>), as characterized by X-ray crystallography and NMR spectroscopy. Two crystal structures and <sup>15</sup>N HSQC experiments reveal a single calixarene binding site in the concave pocket of the β-propeller toroid. Despite the symmetry mismatch between the pentameric protein and the octameric macrocycle, they form a high affinity multivalent co ...[more]
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