Ontology highlight
ABSTRACT:
SUBMITTER: Yalamanchili HK
PROVIDER: S-EPMC10866047 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Yalamanchili Hari Krishna HK Elrod Nathan D ND Jensen Madeline K MK Ji Ping P Lin Ai A Wagner Eric J EJ Liu Zhandong Z
Methods in enzymology 20210605
An increasing number of investigations have established alternative polyadenylation (APA) as a key mechanism of gene regulation through altering the length of 3' untranslated region (UTR) and generating distinct mRNA termini. Further, appreciation for the significance of APA in disease contexts propelled the development of several 3' sequencing techniques. While these RNA sequencing technologies have advanced APA analysis, the intrinsic limitation of 3' read coverage and lack of appropriate comp ...[more]