Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination.
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ABSTRACT:
SUBMITTER: Lyons-Warren AM
PROVIDER: S-EPMC10872518 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
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Co-transmitting interneurons in the mouse olfactory bulb regulate olfactory detection and discrimination.
Lyons-Warren Ariel M AM Tantry Evelyne K EK Moss Elizabeth H EH Kochukov Mikhail Y MY Belfort Benjamin D W BDW Ortiz-Guzman Joshua J Freyberg Zachary Z Arenkiel Benjamin R BR
Cell reports 20231118 12
Co-transmission of multiple neurotransmitters from a single neuron increases the complexity of signaling information within defined neuronal circuits. Superficial short-axon cells in the olfactory bulb release both dopamine and γ-aminobutyric acid (GABA), yet the specific targets of these neurotransmitters and their respective roles in olfaction have remained unknown. Here, we implement intersectional genetics in mice to selectively block GABA or dopamine release from superficial short-axon cell ...[more]
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