Ontology highlight
ABSTRACT:
SUBMITTER: Swarnkar G
PROVIDER: S-EPMC10873594 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Swarnkar Gaurav G Semenkovich Nicholas P NP Arra Manoj M Mims Dorothy K DK Naqvi Syeda Kanwal SK Peterson Timothy T Mbalaviele Gabriel G Wu Chia-Lung CL Abu-Amer Yousef Y
Proceedings of the National Academy of Sciences of the United States of America 20240206 7
Epigenetic regulation plays a crucial role in the pathogenesis of autoimmune diseases such as inflammatory arthritis. DNA hypomethylating agents, such as decitabine (DAC), have been shown to dampen inflammation and restore immune homeostasis. In the present study, we demonstrate that DAC elicits potent anti-inflammatory effects and attenuates disease symptoms in several animal models of arthritis. Transcriptomic and epigenomic profiling show that DAC-mediated hypomethylation regulates a wide ran ...[more]