Ontology highlight
ABSTRACT:
SUBMITTER: Sims AH
PROVIDER: S-EPMC1087583 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Sims Andrew H AH Gent Manda E ME Lanthaler Karin K Dunn-Coleman Nigel S NS Oliver Stephen G SG Robson Geoffrey D GD
Applied and environmental microbiology 20050501 5
Filamentous fungi have a high capacity for producing large amounts of secreted proteins, a property that has been exploited for commercial production of recombinant proteins. However, the secretory pathway, which is key to the production of extracellular proteins, is rather poorly characterized in filamentous fungi compared to yeast. We report the effects of recombinant protein secretion on gene expression levels in Aspergillus nidulans by directly comparing a bovine chymosin-producing strain wi ...[more]