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Prevalence and characterization of invasive isolates of Streptococcus pyogenes with reduced susceptibility to fluoroquinolones.

ABSTRACT: Fluoroquinolone susceptibility testing was performed on invasive group A streptococcus isolates from 1992-1993 and 2003 from Ontario, Canada. None were nonsusceptible to levofloxacin. Two of 153 (1.3%) from 1992-1993 and 7 of 160 (4.4%) from 2003 had a levofloxacin MIC of 2 mug/ml; all nine had parC mutations, and eight were serotype M6.

SUBMITTER: Powis J

PROVIDER: S-EPMC1087656 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature

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Prevalence and characterization of invasive isolates of Streptococcus pyogenes with reduced susceptibility to fluoroquinolones.

Powis Jeff J McGeer Allison A Duncan Carla C Goren Ryan R de Azavedo Joyce C S JC Bast Darrin J DJ Pong-Porter Sylvia S Mazzulli Tony T Green Karen K Willey Barbara B Low Donald E DE

Antimicrobial agents and chemotherapy 20050501 5

Fluoroquinolone susceptibility testing was performed on invasive group A streptococcus isolates from 1992-1993 and 2003 from Ontario, Canada. None were nonsusceptible to levofloxacin. Two of 153 (1.3%) from 1992-1993 and 7 of 160 (4.4%) from 2003 had a levofloxacin MIC of 2 mug/ml; all nine had parC mutations, and eight were serotype M6. ...[more]

PMID: 15855546

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