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JNK3 inhibitors as promising pharmaceuticals with neuroprotective properties.

ABSTRACT: The intensive study and investigation of neuroprotective therapy for central nervous system (CNS) diseases is ongoing. Due to shared mechanisms of neurodegeneration, a neuroprotective approach might offer benefits across multiple neurological disorders, despite variations in symptoms or injuries. C-Jun N-terminal Kinase 3 (JNK3) is found primarily in the CNS and is involved in physiological processes such as brain development, synapse formation, and memory formation. The potential of JNK3 as a target for pharmacological development holds promise for advancing neuroprotective therapies. Developing small molecule JNK3 inhibitors into drugs with neuroprotective qualities could facilitate neuronal restoration and self-repair. This review focuses on elucidating key neuroprotective mechanisms, exploring the interplay between neurodegenerative diseases and neuroprotection, and discussing advancements in JNK3 inhibitor drug development.

SUBMITTER: Wu Y

PROVIDER: S-EPMC10878020 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature

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JNK3 inhibitors as promising pharmaceuticals with neuroprotective properties.

Wu Yibeini Y Zhao Yiling Y Guan Ziman Z Esmaeili Sajjad S Xiao Zhicheng Z Kuriakose Diji D

Cell adhesion & migration 20240215 1

The intensive study and investigation of neuroprotective therapy for central nervous system (CNS) diseases is ongoing. Due to shared mechanisms of neurodegeneration, a neuroprotective approach might offer benefits across multiple neurological disorders, despite variations in symptoms or injuries. C-Jun N-terminal Kinase 3 (JNK3) is found primarily in the CNS and is involved in physiological processes such as brain development, synapse formation, and memory formation. The potential of JNK3 as a t ...[more]

PMID: 38357988

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