Ontology highlight
ABSTRACT:
SUBMITTER: Haqq C
PROVIDER: S-EPMC1087936 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Haqq Christopher C Nosrati Mehdi M Sudilovsky Daniel D Crothers Julia J Khodabakhsh Daniel D Pulliam Brian L BL Federman Scot S Miller James R JR Allen Robert E RE Singer Mark I MI Leong Stanley P L SP Ljung Britt-Marie BM Sagebiel Richard W RW Kashani-Sabet Mohammed M
Proceedings of the National Academy of Sciences of the United States of America 20050415 17
Because of the paucity of available tissue, little information has previously been available regarding the gene expression profiles of primary melanomas. To understand the molecular basis of melanoma progression, we compared the gene expression profiles of a series of nevi, primary melanomas, and melanoma metastases. We found that metastatic melanomas exhibit two dichotomous patterns of gene expression, which unexpectedly reflect gene expression differences already apparent in comparing laser-ca ...[more]