Effectiveness of Casirivimab-Imdevimab and Sotrovimab During a SARS-CoV-2 Delta Variant Surge: A Cohort Study and Randomized Comparative Effectiveness Trial.
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ABSTRACT:
SUBMITTER: Huang DT
PROVIDER: S-EPMC10881222 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
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Effectiveness of Casirivimab-Imdevimab and Sotrovimab During a SARS-CoV-2 Delta Variant Surge: A Cohort Study and Randomized Comparative Effectiveness Trial.
Huang David T DT McCreary Erin K EK Bariola J Ryan JR Minnier Tami E TE Wadas Richard J RJ Shovel Judith A JA Albin Debbie D Marroquin Oscar C OC Kip Kevin E KE Collins Kevin K Schmidhofer Mark M Wisniewski Mary Kay MK Nace David A DA Sullivan Colleen C Axe Meredith M Meyers Russell R Weissman Alexandra A Garrard William W Peck-Palmer Octavia M OM Wells Alan A Bart Robert D RD Yang Anne A Berry Lindsay R LR Berry Scott S Crawford Amy M AM McGlothlin Anna A Khadem Tina T Linstrum Kelsey K Montgomery Stephanie K SK Ricketts Daniel D Kennedy Jason N JN Pidro Caroline J CJ Nakayama Anna A Zapf Rachel L RL Kip Paula L PL Haidar Ghady G Snyder Graham M GM McVerry Bryan J BJ Yealy Donald M DM Angus Derek C DC Seymour Christopher W CW
JAMA network open 20220701 7
<h4>Importance</h4>The effectiveness of monoclonal antibodies (mAbs), casirivimab-imdevimab and sotrovimab, is unknown in patients with mild to moderate COVID-19 caused by the SARS-CoV-2 Delta variant.<h4>Objective</h4>To evaluate the effectiveness of mAb against the Delta variant compared with no mAb treatment and to ascertain the comparative effectiveness of casirivimab-imdevimab and sotrovimab.<h4>Design, setting, and participants</h4>This study comprised 2 parallel studies: (1) a propensity ...[more]
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