Ontology highlight
ABSTRACT:
SUBMITTER: Ferrari M
PROVIDER: S-EPMC10881500 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Ferrari Mathieu M Righi Matteo M Baldan Vania V Wawrzyniecka Patrycja P Bulek Anna A Kinna Alexander A Ma Biao B Bughda Reyisa R Akbar Zulaikha Z Srivastava Saket S Gannon Isaac I Robson Mathew M Sillibourne James J Jha Ram R El-Kholy Mohamed M Amin Oliver Muhammad OM Kokalaki Evangelia E Banani Mohammed Amin MA Hussain Rehan R Day William W Lim Wen Chean WC Ghongane Priyanka P Hopkins Jade R JR Jungherz Dennis D Herling Marco M Welin Martin M Surade Sachin S Dyson Michael M McCafferty John J Logan Derek D Cordoba Shaun S Thomas Simon S Sewell Andrew A Maciocia Paul P Onuoha Shimobi S Pule Martin M
Nature communications 20240221 1
Peripheral T cell lymphomas are typically aggressive with a poor prognosis. Unlike other hematologic malignancies, the lack of target antigens to discriminate healthy from malignant cells limits the efficacy of immunotherapeutic approaches. The T cell receptor expresses one of two highly homologous chains [T cell receptor β-chain constant (TRBC) domains 1 and 2] in a mutually exclusive manner, making it a promising target. Here we demonstrate specificity redirection by rational design using stru ...[more]