Ontology highlight
ABSTRACT:
SUBMITTER: Scott EY
PROVIDER: S-EPMC10882052 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Scott Erica Y EY Safarian Nickie N Casasbuenas Daniela Lozano DL Dryden Michael M Tockovska Teodora T Ali Shawar S Peng Jiaxi J Daniele Emerson E Nie Xin Lim Isabel I Bang K W Annie KWA Tripathy Shreejoy S Yuzwa Scott A SA Wheeler Aaron R AR Faiz Maryam M
Nature communications 20240221 1
Astrocytes, a type of glial cell in the central nervous system (CNS), adopt diverse states in response to injury that are influenced by their location relative to the insult. Here, we describe a platform for spatially resolved, single-cell transcriptomics and proteomics, called tDISCO (tissue-digital microfluidic isolation of single cells for -Omics). We use tDISCO alongside two high-throughput platforms for spatial (Visium) and single-cell transcriptomics (10X Chromium) to examine the heterogen ...[more]