Roundabout4 is essential for angiogenesis in vivo.
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ABSTRACT:
SUBMITTER: Bedell VM
PROVIDER: S-EPMC1088354 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Publications
roundabout4 is essential for angiogenesis in vivo.
Bedell Victoria M VM Yeo Sang-Yeob SY Park Kye Won KW Chung Jeffrey J Seth Pankaj P Shivalingappa Venkatesha V Zhao Jinhua J Obara Tomoko T Sukhatme Vikas P VP Drummond Iain A IA Li Dean Y DY Ramchandran Ramani R
Proceedings of the National Academy of Sciences of the United States of America 20050422 18
Stereotypical patterns of vascular and neuronal networks suggest that specific genetic programs tightly control path determination and, consequently, angiogenesis and axon-guidance mechanisms. Our study focuses on one member of the roundabout family of receptors, which traditionally mediate repulsion from the midline. Here, we characterize a fourth member of this family, roundabout4 (robo4), which is the predominant roundabout (robo) that is expressed in embryonic zebrafish vasculature. Gene kno ...[more]
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