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Mast cells enhance T cell activation: Importance of mast cell-derived TNF.

ABSTRACT: Mast cells are not only important effector cells in immediate hypersensitivity reactions and immune responses to pathogens but also can contribute to T cell-mediated disorders. However, the mechanisms by which mast cells might influence T cells in such settings are not fully understood. We find that mast cells can enhance proliferation and cytokine production in multiple T cell subsets. Mast cell-dependent enhancement of T cell activation can be promoted by FcepsilonRI-dependent mast cell activation, TNF production by both mast cells and T cells, and mast cell-T cell contact. However, at high concentrations of cells, mast cells can promote T cell activation independent of IgE or TNF. Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production.

SUBMITTER: Nakae S

PROVIDER: S-EPMC1088381 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature

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Mast cells enhance T cell activation: Importance of mast cell-derived TNF.

Nakae Susumu S Suto Hajime H Kakurai Maki M Sedgwick Jonathon D JD Tsai Mindy M Galli Stephen J SJ

Proceedings of the National Academy of Sciences of the United States of America 20050419 18

Mast cells are not only important effector cells in immediate hypersensitivity reactions and immune responses to pathogens but also can contribute to T cell-mediated disorders. However, the mechanisms by which mast cells might influence T cells in such settings are not fully understood. We find that mast cells can enhance proliferation and cytokine production in multiple T cell subsets. Mast cell-dependent enhancement of T cell activation can be promoted by FcepsilonRI-dependent mast cell activa ...[more]

PMID: 15840716

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