Current Understanding of Immune Thrombocytopenia: A Review of Pathogenesis and Treatment Options.

ABSTRACT: The management of immune thrombocytopenia (ITP) and the prediction of patient response to therapy still represent a significant and constant challenge in hematology. ITP is a heterogeneous disease with an unpredictable evolution. Although the pathogenesis of ITP is currently better known and its etiology has been extensively studied, up to 75% of adult patients with ITP may develop chronicity, which represents a significant burden on patients' quality of life. A major risk of ITP is bleeding, but knowledge on the exact relationship between the degree of thrombocytopenia and bleeding symptoms, especially at a lower platelet count, is lacking. The actual management of ITP is based on immune suppression (corticosteroids and intravenous immunoglobulins), or the use of thrombopoietin receptor a

SUBMITTER: Mititelu A 

PROVIDER: S-EPMC10889445 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature