Optimized Mass Spectrometry Detection of Thyroid Hormones and Polar Metabolites in Rodent Cerebrospinal Fluid.
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ABSTRACT:
SUBMITTER: Fame RM
PROVIDER: S-EPMC10890085 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
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Optimized Mass Spectrometry Detection of Thyroid Hormones and Polar Metabolites in Rodent Cerebrospinal Fluid.
Fame Ryann M RM Ali Ilhan I Lehtinen Maria K MK Kanarek Naama N Petrova Boryana B
Metabolites 20240123 2
Thyroid hormones (TH) are required for brain development and function. Cerebrospinal fluid (CSF), which bathes the brain and spinal cord, contains TH as free hormones or as bound to transthyretin (TTR). Tight TH level regulation in the central nervous system is essential for developmental gene expression, which governs neurogenesis, myelination, and synaptogenesis. This integrated function of TH highlights the importance of developing precise and reliable methods for assessing TH levels in CSF. ...[more]
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