Ontology highlight
ABSTRACT:
SUBMITTER: Wong SS
PROVIDER: S-EPMC10898259 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Wong Siu-Shing SS Wainman Alan A Saurya Saroj S Raff Jordan W JW
The EMBO journal 20240117 3
Mitotic centrosomes assemble when centrioles recruit large amounts of pericentriolar material (PCM) around themselves. In early C. elegans embryos, mitotic centrosome size appears to be set by the limiting amount of a key component. In Drosophila syncytial embryos, thousands of mitotic centrosomes are assembled as the embryo proceeds through 13 rounds of rapid nuclear division, driven by a core cell cycle oscillator. These divisions slow during nuclear cycles 11-13, and we find that centrosomes ...[more]