Dataset Information

Role of alveolar nitric oxide in gastroesophageal reflux-associated cough: prospective observational study.

ABSTRACT:

Background

Fractional exhaled nitric oxide (FeNO) measured at multiple exhalation flow rates can be used as a biomarker to differentiate central and peripheral airway inflammation. However, the role of alveolar nitric oxide (CaNO) indicating peripheral airway inflammation remains unclear in gastroesophageal reflux-associated cough (GERC).

Objectives

We aimed to characterize the changes in alveolar nitric oxide (CaNO) and determine its clinical implication in GERC.

Design

This is a single-center prospective observational study.

Methods

FeNOs at exhalation flow rates of 50 and 200 ml/s were measured in 102 patients with GERC and 134 patients with other causes of chronic cough (non-GERC). CaNO was calculated based on a two-compartment model and the factors associated with CaNO were analyzed. The effect of anti-reflux therapy on CaNO was examined in 26 GERC patients with elevated CaNO.

Results

CaNO was significantly elevated in GERC compared with that in non-GERC (4.6 ± 4.4 ppb versus 2.8 ± 2.3 ppb, p < 0.001). GERC patients with high CaNO (>5 ppb) had more proximal reflux events (24 ± 15 versus 9 ± 9 episodes, p = 0.001) and a higher level of pepsin (984.8 ± 492.5 versus 634.5 ± 626.4 pg/ml, p = 0.002) in sputum supernatant than those with normal CaNO. More GERC patients with high CaNO required intensified anti-reflux therapy (χ² = 3.963, p = 0.046), as predicted by a sensitivity of 41.7% and specificity of 83.3%. Cough relief paralleled a significant improvement in CaNO (8.3 ± 3.0 versus 4.8 ± 2.6 ppb, p < 0.001).

Conclusion

Peripheral airway inflammation can be assessed by CaNO measurement in GERC. High CaNO indicates potential micro-aspiration and may predict a necessity for intensified anti-reflux therapy.

SUBMITTER: Zhang L

PROVIDER: S-EPMC10898302 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature

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Publications

Role of alveolar nitric oxide in gastroesophageal reflux-associated cough: prospective observational study.

Zhang Li L Zhang Mengru M Aierken Alimire A Dong Ran R Chen Qiang Q Qiu Zhongmin Z

Therapeutic advances in respiratory disease 20240101

<h4>Background</h4>Fractional exhaled nitric oxide (FeNO) measured at multiple exhalation flow rates can be used as a biomarker to differentiate central and peripheral airway inflammation. However, the role of alveolar nitric oxide (CaNO) indicating peripheral airway inflammation remains unclear in gastroesophageal reflux-associated cough (GERC).<h4>Objectives</h4>We aimed to characterize the changes in alveolar nitric oxide (CaNO) and determine its clinical implication in GERC.<h4>Design</h4>Th ...[more]

PMID: 38409671

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Dataset Information

Role of alveolar nitric oxide in gastroesophageal reflux-associated cough: prospective observational study.

Background

Objectives

Design

Methods

Results

Conclusion

Publications

Role of alveolar nitric oxide in gastroesophageal reflux-associated cough: prospective observational study.

Similar Datasets

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