Ontology highlight
ABSTRACT:
SUBMITTER: Wei W
PROVIDER: S-EPMC10900272 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Wei Wei W Tian Linqing L Zheng Xiaoyan X Zhong Lei L Chen Yuan Y Dong Hui H Zhang Guibing G Wang Shibing S Tong Xiangmin X
Oncoimmunology 20240227 1
Pancreatic ductal adenocarcinoma (PDAC) is currently difficult to treat, even when therapies are combined with immune checkpoint blockade (ICB). A novel strategy for immunotherapy would be to maximize the therapeutic potential of oncolytic viruses (OVs), which have been proven to engage the regulation of tumor microenvironment (TME) and cause-specific T-cell responses. To boost tumor sensitivity to ICB therapy, this study aimed to investigate how glutathione peroxide 4 (GPX4)-loaded OVs affect C ...[more]