Prenatal Di-methoxyethyl phthalate exposure impairs cortical neurogenesis and synaptic activity in the mice.
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ABSTRACT:
SUBMITTER: Ko MY
PROVIDER: S-EPMC10901619 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
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Prenatal Di-methoxyethyl phthalate exposure impairs cortical neurogenesis and synaptic activity in the mice.
Ko Moon Yi MY Park Heejin H Chon Sun-Hwa SH Lee Byoung-Seok BS Cha Sin-Woo SW Hyun Sung-Ae SA Ka Minhan M
Brain pathology (Zurich, Switzerland) 20231030 2
Di-methoxyethyl phthalate (DMEP) is a well-known environmentally prevalent endocrine disruptor and may be associated with neurodevelopmental disorders including attention deficit/hyperactivity disorder and intellectual disability. However, the regulatory mechanisms leading to these neurodevelopmental disorders are still poorly understood. Here, we demonstrate that prenatal DMEP exposure causes abnormal brain morphology and function in the mice. DMEP (50 mg/kg) was chronically administered to pre ...[more]
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2020-09-22 | GSE158266 | GEO