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Importance of fatty acid binding proteins in cellular function and organismal metabolism.

ABSTRACT: Fatty acid binding proteins (Fabps) are small soluble proteins that are abundant in the cytosol. These proteins are known to bind a myriad of small hydrophobic molecules and have been postulated to serve a variety of roles, yet their precise functions have remained an enigma over half a century of study. Here, we consider recent findings, along with the cumulative findings contributed by many laboratories working on Fabps over the last half century, to synthesize a new outlook for what functions Fabps serve in cells and organisms. Collectively, the findings illustrate that Fabps function as versatile multi-purpose devices serving as sensors, conveyors and modulators to enable cells to detect and handle a specific class of metabolites, and to adjust their metabolic capacity and efficiency.

SUBMITTER: Agellon LB

PROVIDER: S-EPMC10902576 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Importance of fatty acid binding proteins in cellular function and organismal metabolism.

Agellon Luis B LB

Journal of cellular and molecular medicine 20230306 5

Fatty acid binding proteins (Fabps) are small soluble proteins that are abundant in the cytosol. These proteins are known to bind a myriad of small hydrophobic molecules and have been postulated to serve a variety of roles, yet their precise functions have remained an enigma over half a century of study. Here, we consider recent findings, along with the cumulative findings contributed by many laboratories working on Fabps over the last half century, to synthesize a new outlook for what functions ...[more]

PMID: 36876733

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