Unknown

Dataset Information

0

Thinking process templates for constructing data stories with SCDNEY.


ABSTRACT: Background: Globally, scientists now have the ability to generate a vast amount of high throughput biomedical data that carry critical information for important clinical and public health applications. This data revolution in biology is now creating a plethora of new single-cell datasets. Concurrently, there have been significant methodological advances in single-cell research. Integrating these two resources, creating tailor-made, efficient, and purpose-specific data analysis approaches can assist in accelerating scientific discovery. Methods: We developed a series of living workshops for building data stories, using Single-cell data integrative analysis (scdney). scdney is a wrapper package with a collection of single-cell analysis R packages incorporating data integration, cell type annotation, higher order testing and more. Results: Here, we illustrate two specific workshops. The first workshop examines how to characterise the identity and/or state of cells and the relationship between them, known as phenotyping. The second workshop focuses on extracting higher-order features from cells to predict disease progression. Conclusions: Through these workshops, we not only showcase current solutions, but also highlight critical thinking points. In particular, we highlight the Thinking Process Template that provides a structured framework for the decision-making process behind such single-cell analyses. Furthermore, our workshop will incorporate dynamic contributions from the community in a collaborative learning approach, thus the term 'living'.

SUBMITTER: Cao Y 

PROVIDER: S-EPMC10905113 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

altmetric image

Publications

Thinking process templates for constructing data stories with SCDNEY.

Cao Yue Y   Tran Andy A   Kim Hani H   Robertson Nick N   Lin Yingxin Y   Torkel Marni M   Yang Pengyi P   Patrick Ellis E   Ghazanfar Shila S   Yang Jean J  

F1000Research 20231215


<h4>Background</h4>Globally, scientists now have the ability to generate a vast amount of high throughput biomedical data that carry critical information for important clinical and public health applications. This data revolution in biology is now creating a plethora of new single-cell datasets. Concurrently, there have been significant methodological advances in single-cell research. Integrating these two resources, creating tailor-made, efficient, and purpose-specific data analysis approaches  ...[more]

Similar Datasets

| S-EPMC6002289 | biostudies-literature
| S-EPMC10010083 | biostudies-literature
| S-EPMC3236013 | biostudies-literature
| S-EPMC5682333 | biostudies-literature
| S-EPMC9280381 | biostudies-literature
| S-EPMC6302920 | biostudies-other
| S-EPMC10173455 | biostudies-literature
| S-EPMC8660777 | biostudies-literature
| S-EPMC8802717 | biostudies-literature
| S-EPMC7545503 | biostudies-literature