Ontology highlight
ABSTRACT:
SUBMITTER: Fava A
PROVIDER: S-EPMC10906224 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Fava Andrea A Buyon Jill J Magder Laurence L Hodgin Jeff J Rosenberg Avi A Demeke Dawit S DS Rao Deepak A DA Arazi Arnon A Celia Alessandra Ida AI Putterman Chaim C Anolik Jennifer H JH Barnas Jennifer J Dall'Era Maria M Wofsy David D Furie Richard R Kamen Diane D Kalunian Kenneth K James Judith A JA Guthridge Joel J Atta Mohamed G MG Monroy Trujillo Jose J Fine Derek D Clancy Robert R Belmont H Michael HM Izmirly Peter P Apruzzese William W Goldman Daniel D Berthier Celine C CC Hoover Paul P Hacohen Nir N Raychaudhuri Soumya S Davidson Anne A Diamond Betty B Petri Michelle M
JCI insight 20240123 2
Lupus nephritis (LN) is a pathologically heterogenous autoimmune disease linked to end-stage kidney disease and mortality. Better therapeutic strategies are needed as only 30%-40% of patients completely respond to treatment. Noninvasive biomarkers of intrarenal inflammation may guide more precise approaches. Because urine collects the byproducts of kidney inflammation, we studied the urine proteomic profiles of 225 patients with LN (573 samples) in the longitudinal Accelerating Medicines Partner ...[more]