Ontology highlight
ABSTRACT:
SUBMITTER: Blythe EE
PROVIDER: S-EPMC10907292 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Blythe Emily E EE von Zastrow Mark M
Nature chemical biology 20230925 3
Many G protein-coupled receptors (GPCRs) initiate a second phase of stimulatory heterotrimeric G protein (G<sub>s</sub>)-coupled cAMP signaling after endocytosis. The prevailing current view is that the endosomal signal is inherently β-arrestin-dependent because β-arrestin is necessary for receptor internalization and, for some GPCRs, to prolong the endosomal signal. Here we revise this view by showing that the vasoactive intestinal peptide receptor 1 (VIPR1), a secretin-family polypeptide hormo ...[more]