Ontology highlight
ABSTRACT:
SUBMITTER: Chadchan SB
PROVIDER: S-EPMC10908778 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Chadchan Sangappa B SB Popli Pooja P Liao Zian Z Andreas Eryk E Dias Michelle M Wang Tianyuan T Gunderson Stephanie J SJ Jimenez Patricia T PT Lanza Denise G DG Lanz Rainer B RB Foulds Charles E CE Monsivais Diana D DeMayo Francesco J FJ Yalamanchili Hari Krishna HK Jungheim Emily S ES Heaney Jason D JD Lydon John P JP Moley Kelle H KH O'Malley Bert W BW Kommagani Ramakrishna R
Nature communications 20240302 1
Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor's transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums for steroid receptors are unidentified. Herein, we found that a common feed-forward mechanism between GREB1 and steroid receptors regulates the differential effect of GREB1 on steroid hormones in a physiological or pathological context. In physiological (recepti ...[more]