Exploring the ATG9A interactome uncovers interaction with VPS13A.
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ABSTRACT:
SUBMITTER: van Vliet AR
PROVIDER: S-EPMC10911177 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
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Exploring the ATG9A interactome uncovers interaction with VPS13A.
van Vliet Alexander R AR Jefferies Harold B J HBJ Faull Peter A PA Chadwick Jessica J Ibrahim Fairouz F Skehel Mark J MJ Tooze Sharon A SA
Journal of cell science 20240222 4
ATG9A, a transmembrane protein of the core autophagy pathway, cycles between the Golgi, endosomes and a vesicular compartment. ATG9A was recently shown to act as a lipid scramblase, and this function is thought to require its interaction with another core autophagy protein, ATG2A, which acts as a lipid transfer protein. Together, ATG9A and ATG2A are proposed to function to expand the growing autophagosome. However, ATG9A is implicated in other pathways including membrane repair and lipid droplet ...[more]
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