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Differential functional organization of amygdala-medial prefrontal cortex networks in macaque and human.


ABSTRACT: Over the course of evolution, the amygdala (AMG) and medial frontal cortex (mPFC) network, involved in behavioral adaptation, underwent structural changes in the old-world monkey and human lineages. Yet, whether and how the functional organization of this network differs remains poorly understood. Using resting-state functional magnetic resonance imagery, we show that the functional connectivity (FC) between AMG nuclei and mPFC regions differs between humans and awake macaques. In humans, the AMG-mPFC FC displays U-shaped pattern along the corpus callosum: a positive FC with the ventromedial prefrontal (vmPFC) and anterior cingulate cortex (ACC), a negative FC with the anterior mid-cingulate cortex (MCC), and a positive FC with the posterior MCC. Conversely, in macaques, the negative FC shifted more ventrally at the junction between the vmPFC and the ACC. The functional organization divergence of AMG-mPFC network between humans and macaques might help understanding behavioral adaptation abilities differences in their respective socio-ecological niches.

SUBMITTER: Giacometti C 

PROVIDER: S-EPMC10914752 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Differential functional organization of amygdala-medial prefrontal cortex networks in macaque and human.

Giacometti Camille C   Autran-Clavagnier Delphine D   Dureux Audrey A   Viñales Laura L   Lamberton Franck F   Procyk Emmanuel E   Wilson Charles R E CRE   Amiez Céline C   Hadj-Bouziane Fadila F  

Communications biology 20240305 1


Over the course of evolution, the amygdala (AMG) and medial frontal cortex (mPFC) network, involved in behavioral adaptation, underwent structural changes in the old-world monkey and human lineages. Yet, whether and how the functional organization of this network differs remains poorly understood. Using resting-state functional magnetic resonance imagery, we show that the functional connectivity (FC) between AMG nuclei and mPFC regions differs between humans and awake macaques. In humans, the AM  ...[more]

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