Ontology highlight
ABSTRACT:
SUBMITTER: Wildonger J
PROVIDER: S-EPMC1091738 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Genes & development 20050501 9
We show that reducing the activity of the Drosophila Runx protein Lozenge (Lz) during pupal development causes a decrease in cell death in the eye. We identified Lz-binding sites in introns of argos (aos) and klumpfuss (klu) and demonstrate that these genes are directly activated targets of Lz. Loss of either aos or klu reduces cell death, suggesting that Lz promotes apoptosis at least in part by regulating aos and klu. These results provide novel insights into the control of programmed cell dea ...[more]