Unknown

Dataset Information

0

Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7.


ABSTRACT: Lineage-tracing experiments have shown that some premigratory neural crest cells generate both sensory (S) and autonomic (A) derivatives, whereas others generate only S derivatives. Whether this lineage heterogeneity reflects random variation in a homogeneous population or an early sensory specification of some premigratory crest cells has not been clear. Using Cre recombinase-based fate mapping, we show that GDF7, which is exclusively expressed in the roof plate, marks neural crest cells with a 10-fold higher bias to the sensory lineage than those marked (at the same stage of development) by an inducible Wnt1-Cre, which is expressed more broadly in the dorsal neural tube. In vitro, GDF7 has potent sensory neuron-inducing activity. These data suggest that some premigratory crest cells are deterministically restricted to the S lineage and implicate GDF7 itself in this restriction process.

SUBMITTER: Lo L 

PROVIDER: S-EPMC1091754 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6481292 | biostudies-literature
2012-05-31 | E-GEOD-38381 | biostudies-arrayexpress
| S-EPMC3742142 | biostudies-literature
2012-06-01 | GSE38381 | GEO
| S-EPMC7486307 | biostudies-literature
| S-EPMC3498280 | biostudies-literature
| S-EPMC2717095 | biostudies-literature
| S-EPMC156286 | biostudies-literature
| S-EPMC5100669 | biostudies-literature
| S-EPMC3082303 | biostudies-literature