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Fabrication and properties of hydroxyapatite/chitosan composite scaffolds loaded with periostin for bone regeneration.

ABSTRACT: This paper reports a facile fabrication method of hydroxyapatite/chitosan (HAp/CS) composite scaffold with 3D porous structure without using any chemical cross-linkers. The HAp particles had an urchin-like hollow microstructure and high surface area, which was uniformly dispersed into the pore walls of the HAp/CS scaffold. The addition of HAp can efficiently enhance the mechanical properties and bioactivity of the HAp/CS scaffold. Moreover, periostin was successfully loaded onto the HAp/CS scaffold. When applied to the repair of bone defect in a rat mandibular model, the HAp/CS scaffold loaded with periostin can enhance osteointegration and accelerate bone regeneration. Our research combines periostin with the HAp/CS composite material, which provides a novel strategy to improve bone regeneration and has great application prospect in bone repair fields.

SUBMITTER: Wang H

PROVIDER: S-EPMC10920147 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Fabrication and properties of hydroxyapatite/chitosan composite scaffolds loaded with periostin for bone regeneration.

Wang Huachun H Sun Ruixue R Huang Shengyun S Wu Haiwei H Zhang Dongsheng D

Heliyon 20240217 5

This paper reports a facile fabrication method of hydroxyapatite/chitosan (HAp/CS) composite scaffold with 3D porous structure without using any chemical cross-linkers. The HAp particles had an urchin-like hollow microstructure and high surface area, which was uniformly dispersed into the pore walls of the HAp/CS scaffold. The addition of HAp can efficiently enhance the mechanical properties and bioactivity of the HAp/CS scaffold. Moreover, periostin was successfully loaded onto the HAp/CS scaff ...[more]

PMID: 38463831

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