Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC10924921 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Li Cang C Wang Zhengyu Z Yao Licheng L Lin Xingyu X Jian Yongping Y Li Yujia Y Zhang Jie J Shao Jingwei J Tran Phuc D PD Hagman James R JR Cao Meng M Cong Yusheng Y Li Hong-Yu HY Goding Colin R CR Xu Zhi-Xiang ZX Liao Xuebin X Miao Xiao X Cui Rutao R
Nature communications 20240309 1
Recent development of new immune checkpoint inhibitors has been particularly successfully in cancer treatment, but still the majority patients fail to benefit. Converting resistant tumors to immunotherapy sensitive will provide a significant improvement in patient outcome. Here we identify Mi-2β as a key melanoma-intrinsic effector regulating the adaptive anti-tumor immune response. Studies in genetically engineered mouse melanoma models indicate that loss of Mi-2β rescues the immune response to ...[more]