Ontology highlight
ABSTRACT:
SUBMITTER: Lindsey J
PROVIDER: S-EPMC10925202 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Lindsey Jack J Markowitz Jeffrey E JE Gillis Winthrop F WF Datta Sandeep Robert SR Litwin-Kumar Ashok A
bioRxiv : the preprint server for biology 20241224
Spiny projection neurons (SPNs) in dorsal striatum are often proposed as a locus of reinforcement learning in the basal ganglia. Here, we identify and resolve a fundamental inconsistency between striatal reinforcement learning models and known SPN synaptic plasticity rules. Direct-pathway (dSPN) and indirect-pathway (iSPN) neurons, which promote and suppress actions, respectively, exhibit synaptic plasticity that reinforces activity associated with elevated or suppressed dopamine release. We sho ...[more]