Ontology highlight
ABSTRACT:
SUBMITTER: Ng HY
PROVIDER: S-EPMC10925351 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Ng Henry Y HY Whelpley Devon H DH Adly Armin N AN Maxwell Robert A RA Morgan David O DO
bioRxiv : the preprint server for biology 20250402
Cell cycle progression is governed by complexes of the cyclin-dependent kinases (CDKs) and their regulatory subunits cyclin and Cks1. CDKs phosphorylate hundreds of substrates, often at multiple sites. Multisite phosphorylation depends on Cks1, which binds initial priming phosphorylation sites to promote secondary phosphorylation at other sites. Here, we describe a similar role for a recently discovered phosphate-binding pocket (PP) on B-type cyclins. Mutation of the PP in Clb2, the major mitoti ...[more]