Dataset Information

Association analysis between an epigenetic alcohol risk score and blood pressure.

ABSTRACT:

Background

Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases.

Results

We generated an alcohol consumption epigenetic risk score (ERS) based on previously reported 144 alcohol-associated CpGs and examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. We found an association of alcohol intake with the ERS in the meta-analysis with 0.09 units higher ERS per drink consumed per day (p < 0.0001). Cross-sectional analyses in FHS revealed that a one-unit increment of the ERS was associated with 1.93 mm Hg higher SBP (p = 4.64E-07), 0.68 mm Hg higher DBP (p = 0.006), and an odds ratio of 1.78 for HTN (p < 2E-16). Meta-analysis of the cross-sectional association of the ERS with BP traits in eight independent external cohorts (n = 11,544) showed similar relationships with blood pressure levels, i.e., a one-unit increase in ERS was associated with 0.74 (p = 0.002) and 0.50 (p = 0.0006) mm Hg higher SBP and DBP, but could not confirm the association with hypertension. Longitudinal analyses in FHS (n = 3,260) and five independent external cohorts (n = 4,021) showed that the baseline ERS was not associated with a change in blood pressure over time or with incident HTN.

Conclusions

Our findings provide proof-of-concept that utilizing an ERS is a useful approach to capture the recent health consequences of lifestyle behaviors such as alcohol consumption.

SUBMITTER: Bui H

PROVIDER: S-EPMC10925472 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Publications

Association analysis between an epigenetic alcohol risk score and blood pressure.

Bui Helena H Keshawarz Amena A Wang Mengyao M Lee Mikyeong M Ratliff Scott M SM Lin Lisha L Birditt Kira S KS Faul Jessica D JD Peters Annette A Gieger Christian C Delerue Thomas T Kardia Sharon L R SLR Zhao Wei W Guo Xiuqing X Yao Jie J Rotter Jerome I JI Li Yi Y Liu Xue X Liu Dan D Tavares Juliana F JF Pehlivan Gökhan G Breteler Monique M B MMB Karabegovic Irma I Ochoa-Rosales Carolina C Voortman Trudy T Ghanbari Mohsen M van Meurs Joyce B J JBJ Nasr Mohamed Kamal MK Dörr Marcus M Grabe Hans J HJ London Stephanie J SJ Teumer Alexander A Waldenberger Melanie M Weir David R DR Smith Jennifer A JA Levy Daniel D Ma Jiantao J Liu Chunyu C

medRxiv : the preprint server for health sciences 20240411

<h4>Background</h4>Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases.<h4>Results</h4>We generated an alcohol consumption epigenetic risk score (ERS) based on previously reported 144 alcohol-associated CpGs and examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart ...[more]

PMID: 38464320

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Dataset Information

Association analysis between an epigenetic alcohol risk score and blood pressure.

Background

Results

Conclusions

Publications

Association analysis between an epigenetic alcohol risk score and blood pressure.

Similar Datasets

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