Ontology highlight
ABSTRACT:
SUBMITTER: Nurminsky DI
PROVIDER: S-EPMC109265 | biostudies-literature | 1998 Nov
REPOSITORIES: biostudies-literature
Nurminsky D I DI Nurminskaya M V MV Benevolenskaya E V EV Shevelyov Y Y YY Hartl D L DL Gvozdev V A VA
Molecular and cellular biology 19981101 11
The intermediate chains (ICs) are the subunits of the cytoplasmic dynein that provide binding of the complex to cargo organelles through interaction of their N termini with dynactin. We present evidence that in Drosophila, the IC subunits are represented by at least 10 structural isoforms, created by the alternative splicing of transcripts from a unique Cdic gene. The splicing pattern is tissue specific. A constitutive set of four IC isoforms is expressed in all tissues tested; in addition, tiss ...[more]