Dataset Information

Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts.

ABSTRACT:

Background

Smartphone-based cognitive assessments have emerged as promising tools, bridging gaps in accessibility and reducing bias in Alzheimer disease and related dementia research. However, their congruence with traditional neuropsychological tests and usefulness in diverse cohorts remain underexplored.

Methods and results

A total of 406 FHS (Framingham Heart Study) and 59 BHS (Bogalusa Heart Study) participants with traditional neuropsychological tests and digital assessments using the Defense Automated Neurocognitive Assessment (DANA) smartphone protocol were included. Regression models investigated associations between DANA task digital measures and a neuropsychological global cognitive Z score (Global Cognitive Score [GCS]), and neuropsychological domain-specific Z scores. FHS participants' mean age was 57 (SD, 9.75) years, and 44% (179) were men. BHS participants' mean age was 49 (4.4) years, and 28% (16) were men. Participants in both cohorts with the lowest neuropsychological performance (lowest quartile, GCS1) demonstrated lower DANA digital scores. In the FHS, GCS1 participants had slower average response times and decreased cognitive efficiency scores in all DANA tasks (P<0.05). In BHS, participants in GCS1 had slower average response times and decreased cognitive efficiency scores for DANA Code Substitution and Go/No-Go tasks, although this was not statistically significant. In both cohorts, GCS was significantly associated with DANA tasks, such that higher GCS correlated with faster average response times (P<0.05) and increased cognitive efficiency (all P<0.05) in the DANA Code Substitution task.

Conclusions

Our findings demonstrate that smartphone-based cognitive assessments exhibit concurrent validity with a composite measure of traditional neuropsychological tests. This supports the potential of using smartphone-based assessments in cognitive screening across diverse populations and the scalability of digital assessments to community-dwelling individuals.

SUBMITTER: De Anda-Duran I

PROVIDER: S-EPMC10926794 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Publications

Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts.

De Anda-Duran Ileana I Sunderaraman Preeti P Searls Edward E Moukaled Shirine S Jin Xuanyi X Popp Zachary Z Karjadi Cody C Hwang Phillip H PH Ding Huitong H Devine Sherral S Shih Ludy C LC Low Spencer S Lin Honghuang H Kolachalama Vijaya B VB Bazzano Lydia L Libon David J DJ Au Rhoda R

Journal of the American Heart Association 20240116 2

<h4>Background</h4>Smartphone-based cognitive assessments have emerged as promising tools, bridging gaps in accessibility and reducing bias in Alzheimer disease and related dementia research. However, their congruence with traditional neuropsychological tests and usefulness in diverse cohorts remain underexplored.<h4>Methods and results</h4>A total of 406 FHS (Framingham Heart Study) and 59 BHS (Bogalusa Heart Study) participants with traditional neuropsychological tests and digital assessments ...[more]

PMID: 38226519

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Dataset Information

Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts.

Background

Methods and results

Conclusions

Publications

Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts.

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