Ontology highlight
ABSTRACT:
SUBMITTER: Simula L
PROVIDER: S-EPMC10928223 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Simula Luca L Fumagalli Mattia M Vimeux Lene L Rajnpreht Irena I Icard Philippe P Birsen Gary G An Dongjie D Pendino Frédéric F Rouault Adrien A Bercovici Nadège N Damotte Diane D Lupo-Mansuet Audrey A Alifano Marco M Alves-Guerra Marie-Clotilde MC Donnadieu Emmanuel E
Nature communications 20240311 1
The ability of CD8<sup>+</sup> T cells to infiltrate solid tumors and reach cancer cells is associated with improved patient survival and responses to immunotherapy. Thus, identifying the factors controlling T cell migration in tumors is critical, so that strategies to intervene on these targets can be developed. Although interstitial motility is a highly energy-demanding process, the metabolic requirements of CD8<sup>+</sup> T cells migrating in a 3D environment remain unclear. Here, we demonst ...[more]