Ontology highlight
ABSTRACT:
SUBMITTER: Ugusman A
PROVIDER: S-EPMC10932471 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Ugusman Azizah A Ismail Siti Marjiana SM Nor Hisam Nur Syahidah NS Hui Chua Kien CK Saleh Mohammed S M MSM Abdul Karim Abdul Kadir AK Othman Nur Syakirah NS Hamid Adila A AA Aminuddin Amilia A
International journal of molecular sciences 20240228 5
Angiotensin-converting enzyme (ACE) plays a crucial role in the pathogenesis of hypertension. <i>Piper sarmentosum</i> Roxb., an herb known for its antihypertensive effect, lacks a comprehensive understanding of the mechanism underlying its antihypertensive action. This study aimed to elucidate the antihypertensive mechanism of aqueous extract of <i>P. sarmentosum</i> leaves (AEPS) via its modulation of the ACE pathway in phorbol 12-myristate-13-acetate (PMA)-induced human umbilical vein endothe ...[more]