Ontology highlight
ABSTRACT:
SUBMITTER: Pertinez H
PROVIDER: S-EPMC10942359 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Pertinez Henry H Kaushik Amit A Curley Paul P Arshad Usman U El-Khateeb Eman E Li Si-Yang SY Tasneen Rokeya R Sharp Joanne J Kijak Edyta E Herriott Joanne J Neary Megan M Noë Michaël M Flexner Charles C Nuermberger Eric E Owen Andrew A Ammerman Nicole C NC
bioRxiv : the preprint server for biology 20240306
A significant challenge in the development of long-acting injectable drug formulations, especially for anti-infective agents, is delivering an efficacious dose within a tolerable injection volume. Co-administration of the extracellular matrix-degrading enzyme hyaluronidase can increase maximum tolerable injection volumes but is untested for this benefit with long-acting injectable formulations. One concern is that hyaluronidase could potentially alter the tissue response surrounding an injection ...[more]