Ontology highlight
ABSTRACT:
SUBMITTER: Gu Y
PROVIDER: S-EPMC10949200 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Gu Yushu Y Liu Miaomiao M Ma Linlin L Quinn Ronald J RJ
ACS chemical biology 20240307 3
The inwardly rectifying potassium Kir4.2 channel plays a crucial role in regulating membrane potentials and maintaining potassium homeostasis. Kir4.2 has been implicated in various physiological processes, including insulin secretion, gastric acid regulation, and the pathogenesis of central nervous system diseases. Despite its significance, the number of identified ligands for Kir4.2 remains limited. In this study, we established a method to directly observe ligands avoiding a requirement to obs ...[more]