Dataset Information

Sickle cell trait in Sao Tome e Principe: a population-based prevalence study in women of reproductive age.

ABSTRACT:

Background

Sickle Cell Disorder is Africa's most prevalent genetic disease. Yet, it remains a neglected condition, with high mortality under-five, and a lack of population-based studies in the region. This is the first of its kind in São Tomé e Príncipe, aiming to estimate the prevalence of sickle cell trait and other haemoglobin variants in women of reproductive age and its associated factors.

Methods

We conducted a cluster survey in 35 neighbourhoods. Haemoglobin was assessed through point-of-care capillary electrophoresis or high-performance liquid chromatography, and sociodemographic data through questionnaires. The weighted prevalence of sickle cell trait (HbAS) and HbC carriers was estimated with a 95% confidence interval (95% CI). We calculated weighted prevalence ratios (95% CI) through robust Poisson regression for its association with age and individual and collective genetic heritage.

Findings

The prevalence of sickle cell trait in women of reproductive age in São Tomé e Príncipe (n = 376) was 13.45% (95% CI: 9.05-19.00). The prevalence of HbC carriers was 8.00% (95% CI: 4.71-12.00). Older age and speaking Forro or Angolar were positively associated with having sickle cell trait.

Interpretation

The prevalence of sickle cell trait in São Tomé e Príncipe ranks high in the West African region. The country should follow international guidelines, implementing newborn screening and comprehensive healthcare management.

SUBMITTER: Queiroz G

PROVIDER: S-EPMC10949760 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Sickle cell trait in São Tomé e Príncipe: a population-based prevalence study in women of reproductive age.

Queiroz Guilherme G Monteiro Celdidy C Manco Licínio L Relvas Luís L Trovoada Maria de Jesus MJ Leite Andreia A Bento Celeste C

BMC public health 20240319 1

<h4>Background</h4>Sickle Cell Disorder is Africa's most prevalent genetic disease. Yet, it remains a neglected condition, with high mortality under-five, and a lack of population-based studies in the region. This is the first of its kind in São Tomé e Príncipe, aiming to estimate the prevalence of sickle cell trait and other haemoglobin variants in women of reproductive age and its associated factors.<h4>Methods</h4>We conducted a cluster survey in 35 neighbourhoods. Haemoglobin was assessed th ...[more]

PMID: 38504224

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