Ontology highlight
ABSTRACT:
SUBMITTER: Tang AS
PROVIDER: S-EPMC10950787 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Tang Alice S AS Rankin Katherine P KP Cerono Gabriel G Miramontes Silvia S Mills Hunter H Roger Jacquelyn J Zeng Billy B Nelson Charlotte C Soman Karthik K Woldemariam Sarah S Li Yaqiao Y Lee Albert A Bove Riley R Glymour Maria M Aghaeepour Nima N Oskotsky Tomiko T TT Miller Zachary Z Allen Isabel E IE Sanders Stephan J SJ Baranzini Sergio S Sirota Marina M
Nature aging 20240221 3
Identification of Alzheimer's disease (AD) onset risk can facilitate interventions before irreversible disease progression. We demonstrate that electronic health records from the University of California, San Francisco, followed by knowledge networks (for example, SPOKE) allow for (1) prediction of AD onset and (2) prioritization of biological hypotheses, and (3) contextualization of sex dimorphism. We trained random forest models and predicted AD onset on a cohort of 749 individuals with AD and ...[more]