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Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges.


ABSTRACT: The clinical advancement of protein-based nanomedicine has revolutionized medical professionals' perspectives on cancer therapy. Protein-based nanoparticles have been exploited as attractive vehicles for cancer nanomedicine due to their unique properties derived from naturally biomacromolecules with superior biocompatibility and pharmaceutical features. Furthermore, the successful translation of Abraxane™ (paclitaxel-based albumin nanoparticles) into clinical application opened a new avenue for protein-based cancer nanomedicine. In this mini-review article, we demonstrate the rational design and recent progress of protein-based nanoparticles along with their applications in cancer diagnosis and therapy from recent literature. The current challenges and hurdles that hinder clinical application of protein-based nanoparticles are highlighted. Finally, future perspectives for translating protein-based nanoparticles into clinic are identified.

SUBMITTER: Fan Z 

PROVIDER: S-EPMC10951516 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature

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Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges.

Fan Zhechen Z   Iqbal Haroon H   Ni Jiang J   Khan Naveed Ullah NU   Irshad Shahla S   Razzaq Anam A   Alfaifi Mohammad Y MY   Elbehairi Serag Eldin I SEI   Shati Ali A AA   Zhou Jianping J   Cheng Hao H  

International journal of pharmaceutics: X 20240311


The clinical advancement of protein-based nanomedicine has revolutionized medical professionals' perspectives on cancer therapy. Protein-based nanoparticles have been exploited as attractive vehicles for cancer nanomedicine due to their unique properties derived from naturally biomacromolecules with superior biocompatibility and pharmaceutical features. Furthermore, the successful translation of Abraxane™ (paclitaxel-based albumin nanoparticles) into clinical application opened a new avenue for  ...[more]

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