Ontology highlight
ABSTRACT:
SUBMITTER: Peng W
PROVIDER: S-EPMC10955041 | biostudies-literature | 2024 Jun
REPOSITORIES: biostudies-literature
Peng Weiwei W Giesbers Koen Cap KC Šiborová Marta M Beugelink J Wouter JW Pronker Matti F MF Schulte Douwe D Hilkens John J Janssen Bert Jc BJ Strijbis Karin K Snijder Joost J
Life science alliance 20240320 6
Mucin 1 (MUC1) is a transmembrane mucin expressed at the apical surface of epithelial cells at mucosal surfaces. MUC1 has a barrier function against bacterial invasion and is well known for its aberrant expression and glycosylation in adenocarcinomas. The MUC1 extracellular domain contains a variable number of tandem repeats (VNTR) of 20 amino acids, which are heavily <i>O</i>-linked glycosylated. Monoclonal antibodies against the MUC1 VNTR are powerful research tools with applications in the di ...[more]