Ontology highlight
ABSTRACT:
SUBMITTER: Castegnaro A
PROVIDER: S-EPMC10957396 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Castegnaro Andrea A Ji Zilong Z Rudzka Katarzyna K Chan Dennis D Burgess Neil N
Current biology : CB 20231011 21
Path integration (PI) is impaired early in Alzheimer's disease (AD) but reflects multiple sub-processes that may be differentially sensitive to AD. To characterize these sub-processes, we developed a novel generative linear-angular model of PI (GLAMPI) to fit the inbound paths of healthy elderly participants performing triangle completion, a popular PI task, in immersive virtual reality with real movement. The model fits seven parameters reflecting the encoding, calculation, and production error ...[more]