Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez-Beltran JCR
PROVIDER: S-EPMC10960800 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Hernandez-Beltran J Carlos R JCR Rodríguez-Beltrán Jerónimo J Aguilar-Luviano Oscar Bruno OB Velez-Santiago Jesús J Mondragón-Palomino Octavio O MacLean R Craig RC Fuentes-Hernández Ayari A San Millán Alvaro A Peña-Miller Rafael R
Nature communications 20240323 1
The rise of antibiotic resistance is a critical public health concern, requiring an understanding of mechanisms that enable bacteria to tolerate antimicrobial agents. Bacteria use diverse strategies, including the amplification of drug-resistance genes. In this paper, we showed that multicopy plasmids, often carrying antibiotic resistance genes in clinical bacteria, can rapidly amplify genes, leading to plasmid-mediated phenotypic noise and transient antibiotic resistance. By combining stochasti ...[more]