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Use of Baricitinib in a patient with treatment-resistant pyoderma gangrenosum.

ABSTRACT: Pyoderma gangrenosum is a rare inflammatory neutrophilic disorder with no uniformly effective therapy and limited high-level evidence. Common therapies include immunosuppressive and immunomodulating agents. There exist several case series using small molecules as treatment modalities. Here, we report a case of a 78-year-old female with a diagnosis of pyoderma gangrenosum and metastatic high-grade serous carcinoma of the ovary who was treated with Baricitinib 4 mg daily in combination with a tapering course of prednisone after failing other conventional therapies including systemic corticosteroids, colchicine, and intravenous immunoglobulin.

SUBMITTER: Bechard K

PROVIDER: S-EPMC10960974 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Use of Baricitinib in a patient with treatment-resistant pyoderma gangrenosum.

Bechard Kaylin K Gniadecki Robert R

SAGE open medical case reports 20240323

Pyoderma gangrenosum is a rare inflammatory neutrophilic disorder with no uniformly effective therapy and limited high-level evidence. Common therapies include immunosuppressive and immunomodulating agents. There exist several case series using small molecules as treatment modalities. Here, we report a case of a 78-year-old female with a diagnosis of pyoderma gangrenosum and metastatic high-grade serous carcinoma of the ovary who was treated with Baricitinib 4 mg daily in combination with a tape ...[more]

PMID: 38524384

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