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Clinical impacts of scar reduction on gated myocardial perfusion SPECT after cardiac resynchronization therapy.


ABSTRACT:

Background

It had not been reported that myocardial scar shown on gated myocardial perfusion SPECT (GMPS) might reduce after cardiac resynchronization therapy (CRT). In this study, we aim to investigate the clinical impact and characteristic of scar reduction (SR) after CRT.

Methods and results

Sixty-one heart failure patients following standard indication for CRT received twice GMPS as pre- and post-CRT evaluations. The patients with an absolute reduction of scar ≥ 10% after CRT were classified as the SR group while the rest were classified as the non-SR group. The SR group (N = 22, 36%) showed more improvement on LV function (∆LVEF: 18.1 ± 12.4 vs 9.4 ± 9.9 %, P = 0.007, ∆ESV: - 91.6 ± 52.6 vs - 38.1 ± 46.5 mL, P < 0.001) and dyssynchrony (ΔPSD: - 26.19 ± 18.42 vs - 5.8 ± 23.0°, P < 0.001, Δ BW: - 128.7 ± 82.8 vs - 25.2 ± 109.0°, P < 0.001) than non-SR group (N = 39, 64%). Multivariate logistic regression analysis showed baseline QRSd (95% CI 1.019-1.100, P = 0.006) and pre-CRT Reduced Wall Thickening (RWT) (95% CI 1.016-1.173, P = 0.028) were independent predictors for the development of SR.

Conclusion

More than one third of patients showed SR after CRT who had more post-CRT improvement on LV function and dyssynchrony than those without SR. Wider QRSd and higher RWT before CRT were related to the development of SR after CRT.

SUBMITTER: Wang CY 

PROVIDER: S-EPMC10961135 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

Clinical impacts of scar reduction on gated myocardial perfusion SPECT after cardiac resynchronization therapy.

Wang Chi-Yen CY   Hung Guang-Uei GU   Lo Hsu-Chung HC   Tsai Shih-Chuan SC   He Zhuo Z   Zhang Xinwei X   Chiang Kuo-Feng KF   Zou Jiangang J   Zhou Weihua W   Huang Jin-Long JL   Chen Shih-Ann SA  

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20210819 5


<h4>Background</h4>It had not been reported that myocardial scar shown on gated myocardial perfusion SPECT (GMPS) might reduce after cardiac resynchronization therapy (CRT). In this study, we aim to investigate the clinical impact and characteristic of scar reduction (SR) after CRT.<h4>Methods and results</h4>Sixty-one heart failure patients following standard indication for CRT received twice GMPS as pre- and post-CRT evaluations. The patients with an absolute reduction of scar ≥ 10% after CRT  ...[more]

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