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Overcoming microbial resuscitation using stable ultrafine gold nanosystems.


ABSTRACT: While ultrafine gold nanosystems (UGNs) are being extensively studied for their antimicrobial activities, hitherto, no report is available on their propensity towards mitigating bacterial resuscitation-a potential factor contributing to the antimicrobial resistance. The investigations herein with two categories of gold nanosystems-modulated for their stability and surface accessibility through glutathione capping-have provided insights into overcoming resuscitation. Additionally, the study cautions that even moderate resistance development in bacteria exposed to nanosystems can result in significant cross-resistance against conventional antibiotics.

SUBMITTER: Thakur A 

PROVIDER: S-EPMC10964751 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Overcoming microbial resuscitation using stable ultrafine gold nanosystems.

Thakur Anindita A   Maroju Pranay Amruth PA   Ganesan Ramakrishnan R   Ray Dutta Jayati J  

Nanoscale advances 20240307 7


While ultrafine gold nanosystems (UGNs) are being extensively studied for their antimicrobial activities, hitherto, no report is available on their propensity towards mitigating bacterial resuscitation-a potential factor contributing to the antimicrobial resistance. The investigations herein with two categories of gold nanosystems-modulated for their stability and surface accessibility through glutathione capping-have provided insights into overcoming resuscitation. Additionally, the study cauti  ...[more]

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