Ontology highlight
ABSTRACT:
SUBMITTER: Duwor S
PROVIDER: S-EPMC10968658 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Duwor Seth S Brites Daniela D Mäser Pascal P
Biology 20240309 3
The present frontrunners in the chemotherapy of infections caused by protozoa are nitro-based prodrugs that are selectively activated by PFOR-mediated redox reactions. This study seeks to analyze the distribution of PFOR in selected protozoa and bacteria by applying comparative genomics to test the hypothesis that PFOR in eukaryotes was acquired through horizontal gene transfer (HGT) from bacteria. Furthermore, to identify other putatively acquired genes, proteome-wide and gene enrichment analys ...[more]